Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice.

Mackenzie, Gerardo G

Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice. [electronic resource] - PloS one 2013 - e61532 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0061532 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis
Cell Line, Tumor
Cimetidine--pharmacology
Drug Synergism
Female
Humans
Membrane Potential, Mitochondrial--drug effects
Mice
Mice, Inbred BALB C
Mice, Nude
Mitochondria--drug effects
Molecular Targeted Therapy
Organophosphates--pharmacology
Pancreatic Neoplasms--drug therapy
Protein Transport--drug effects
Reactive Oxygen Species--metabolism
STAT3 Transcription Factor--metabolism
Signal Transduction--drug effects
Tumor Burden--drug effects
Valproic Acid--analogs & derivatives
Xenograft Model Antitumor Assays