Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligand sensing domain of ASIC3 channel. [electronic resource]
Producer: 20130426Description: 4265-79 p. digitalISSN:- 1529-2401
- Acid Sensing Ion Channels -- chemistry
- Action Potentials -- drug effects
- Analysis of Variance
- Animals
- CHO Cells
- Calcium -- metabolism
- Cricetinae
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Ganglia, Spinal -- cytology
- Gene Expression Regulation -- drug effects
- Glutamic Acid -- pharmacology
- Humans
- Hydrogen-Ion Concentration
- Ligands
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mutagenesis, Site-Directed
- Nerve Tissue Proteins -- metabolism
- Neuralgia -- physiopathology
- Neurons -- drug effects
- Pain Threshold -- drug effects
- Protein Binding -- drug effects
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-fos -- metabolism
- Protons
- Radioligand Assay
- Rats
- Receptor, Serotonin, 5-HT2C -- genetics
- Serotonin -- pharmacology
- Serotonin Agents -- pharmacology
- Spinal Cord -- metabolism
- Transfection
- Tritium -- pharmacokinetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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