Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligand sensing domain of ASIC3 channel.

Wang, Xiang

Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligand sensing domain of ASIC3 channel. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Mar 2013 - 4265-79 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1529-2401

10.1523/JNEUROSCI.3376-12.2013 doi


Acid Sensing Ion Channels--chemistry
Action Potentials--drug effects
Analysis of Variance
Animals
CHO Cells
Calcium--metabolism
Cricetinae
Disease Models, Animal
Dose-Response Relationship, Drug
Ganglia, Spinal--cytology
Gene Expression Regulation--drug effects
Glutamic Acid--pharmacology
Humans
Hydrogen-Ion Concentration
Ligands
Mice
Mice, Inbred C57BL
Mice, Knockout
Mutagenesis, Site-Directed
Nerve Tissue Proteins--metabolism
Neuralgia--physiopathology
Neurons--drug effects
Pain Threshold--drug effects
Protein Binding--drug effects
Protein Structure, Tertiary
Proto-Oncogene Proteins c-fos--metabolism
Protons
Radioligand Assay
Rats
Receptor, Serotonin, 5-HT2C--genetics
Serotonin--pharmacology
Serotonin Agents--pharmacology
Spinal Cord--metabolism
Transfection
Tritium--pharmacokinetics