Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS. [electronic resource]
Producer: 20130806Description: e57152 p. digitalISSN:- 1932-6203
- Acetylcysteine -- pharmacology
- Antineoplastic Agents, Phytogenic -- pharmacology
- Apoptosis -- drug effects
- Cell Cycle Proteins -- genetics
- Cell Line, Tumor
- Curcumin -- pharmacology
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- MAP Kinase Signaling System -- drug effects
- Nerve Sheath Neoplasms -- complications
- Neurofibromatosis 1 -- complications
- Neurofibromin 1 -- antagonists & inhibitors
- Nuclear Proteins -- genetics
- Phosphatidylinositol 3-Kinases -- genetics
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-akt -- genetics
- Proto-Oncogene Proteins c-myc -- genetics
- Reactive Oxygen Species -- antagonists & inhibitors
- Receptors, TNF-Related Apoptosis-Inducing Ligand -- genetics
- Schwann Cells -- drug effects
- Signal Transduction -- drug effects
- TNF-Related Apoptosis-Inducing Ligand -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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