Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.

Reuss, David E

Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS. [electronic resource] - PloS one 2013 - e57152 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1932-6203

10.1371/journal.pone.0057152 doi


Acetylcysteine--pharmacology
Antineoplastic Agents, Phytogenic--pharmacology
Apoptosis--drug effects
Cell Cycle Proteins--genetics
Cell Line, Tumor
Curcumin--pharmacology
Gene Expression Regulation, Neoplastic--drug effects
Humans
MAP Kinase Signaling System--drug effects
Nerve Sheath Neoplasms--complications
Neurofibromatosis 1--complications
Neurofibromin 1--antagonists & inhibitors
Nuclear Proteins--genetics
Phosphatidylinositol 3-Kinases--genetics
Protein Structure, Tertiary
Proto-Oncogene Proteins c-akt--genetics
Proto-Oncogene Proteins c-myc--genetics
Reactive Oxygen Species--antagonists & inhibitors
Receptors, TNF-Related Apoptosis-Inducing Ligand--genetics
Schwann Cells--drug effects
Signal Transduction--drug effects
TNF-Related Apoptosis-Inducing Ligand--genetics