CYP3A4 genetic status may be associated with increased vulnerability to the inhibitory effect of calcium-channel blockers on clopidogrel. [electronic resource]
Producer: 20131031Description: 1289-96 p. digitalISSN:- 1347-4820
- Aged
- Blood Platelets -- drug effects
- Calcium Channel Blockers -- therapeutic use
- Chi-Square Distribution
- Clopidogrel
- Cytochrome P-450 CYP3A -- genetics
- Cytochrome P-450 CYP3A Inhibitors
- Drug Interactions
- Enzyme Inhibitors -- therapeutic use
- Female
- Gene Frequency
- Genotype
- Humans
- Linear Models
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Odds Ratio
- Pharmacogenetics
- Phenotype
- Platelet Aggregation -- drug effects
- Platelet Aggregation Inhibitors -- administration & dosage
- Platelet Function Tests
- Prospective Studies
- Purinergic P2Y Receptor Antagonists -- administration & dosage
- Receptors, Purinergic P2Y12 -- blood
- Risk Factors
- Ticlopidine -- administration & dosage
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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