CYP3A4 genetic status may be associated with increased vulnerability to the inhibitory effect of calcium-channel blockers on clopidogrel.

Park, Jin Joo

CYP3A4 genetic status may be associated with increased vulnerability to the inhibitory effect of calcium-channel blockers on clopidogrel. [electronic resource] - Circulation journal : official journal of the Japanese Circulation Society 2013 - 1289-96 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1347-4820

10.1253/circj.cj-12-0682 doi


Aged
Blood Platelets--drug effects
Calcium Channel Blockers--therapeutic use
Chi-Square Distribution
Clopidogrel
Cytochrome P-450 CYP3A--genetics
Cytochrome P-450 CYP3A Inhibitors
Drug Interactions
Enzyme Inhibitors--therapeutic use
Female
Gene Frequency
Genotype
Humans
Linear Models
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Pharmacogenetics
Phenotype
Platelet Aggregation--drug effects
Platelet Aggregation Inhibitors--administration & dosage
Platelet Function Tests
Prospective Studies
Purinergic P2Y Receptor Antagonists--administration & dosage
Receptors, Purinergic P2Y12--blood
Risk Factors
Ticlopidine--administration & dosage