LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans. [electronic resource]
Producer: 20130920Description: 197-209 p. digitalISSN:- 1932-7420
- 3T3-L1 Cells
- Animals
- Cells, Cultured
- Fibroblasts -- drug effects
- Gene Knockdown Techniques
- Glucose -- metabolism
- Glucose Tolerance Test
- Humans
- Insulin -- pharmacology
- Insulin Receptor Substrate Proteins -- metabolism
- Low Density Lipoprotein Receptor-Related Protein-6 -- genetics
- Mechanistic Target of Rapamycin Complex 1
- Mice
- Models, Biological
- Multiprotein Complexes -- metabolism
- Muscle, Skeletal -- drug effects
- Mutation -- genetics
- Phosphoserine -- metabolism
- Protein Stability -- drug effects
- Receptor, IGF Type 1 -- metabolism
- Receptor, Insulin -- genetics
- Skin -- cytology
- TOR Serine-Threonine Kinases -- metabolism
- Transcription Factor 7-Like 2 Protein -- metabolism
- Transcription, Genetic -- drug effects
- Wnt Signaling Pathway -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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