LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans.

Singh, Rajvir

LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans. [electronic resource] - Cell metabolism Feb 2013 - 197-209 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1932-7420

10.1016/j.cmet.2013.01.009 doi


3T3-L1 Cells
Animals
Cells, Cultured
Fibroblasts--drug effects
Gene Knockdown Techniques
Glucose--metabolism
Glucose Tolerance Test
Humans
Insulin--pharmacology
Insulin Receptor Substrate Proteins--metabolism
Low Density Lipoprotein Receptor-Related Protein-6--genetics
Mechanistic Target of Rapamycin Complex 1
Mice
Models, Biological
Multiprotein Complexes--metabolism
Muscle, Skeletal--drug effects
Mutation--genetics
Phosphoserine--metabolism
Protein Stability--drug effects
Receptor, IGF Type 1--metabolism
Receptor, Insulin--genetics
Skin--cytology
TOR Serine-Threonine Kinases--metabolism
Transcription Factor 7-Like 2 Protein--metabolism
Transcription, Genetic--drug effects
Wnt Signaling Pathway--drug effects