Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine. [electronic resource]
Producer: 20130702Description: 374-82 p. digitalISSN:- 0946-1965
- Anti-Arrhythmia Agents -- administration & dosage
- Antidepressive Agents -- administration & dosage
- Biotransformation
- Chemistry, Pharmaceutical
- Computer Simulation
- Cytochrome P-450 CYP2D6 -- metabolism
- Cytochrome P-450 CYP2D6 Inhibitors
- Delayed-Action Preparations
- Drug Dosage Calculations
- Drug Interactions
- Enzyme Inhibitors -- administration & dosage
- Humans
- Metoprolol -- administration & dosage
- Models, Biological
- Nonlinear Dynamics
- Paroxetine -- administration & dosage
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Publication Type: Journal Article
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