Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine.

Mikami, Akiko

Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine. [electronic resource] - International journal of clinical pharmacology and therapeutics May 2013 - 374-82 p. digital

Publication Type: Journal Article

0946-1965

10.5414/CP201798 doi


Anti-Arrhythmia Agents--administration & dosage
Antidepressive Agents--administration & dosage
Biotransformation
Chemistry, Pharmaceutical
Computer Simulation
Cytochrome P-450 CYP2D6--metabolism
Cytochrome P-450 CYP2D6 Inhibitors
Delayed-Action Preparations
Drug Dosage Calculations
Drug Interactions
Enzyme Inhibitors--administration & dosage
Humans
Metoprolol--administration & dosage
Models, Biological
Nonlinear Dynamics
Paroxetine--administration & dosage