KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer. [electronic resource]
Producer: 20130430Description: 74-82 p. digitalISSN:- 1872-7980
- Aminopyridines -- chemistry
- Angiogenesis Inhibitors -- chemistry
- Animals
- Antigens, CD34 -- metabolism
- Apoptosis -- drug effects
- Benzoxazoles -- chemistry
- Caspase 3 -- metabolism
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- DNA Fragmentation
- Dose-Response Relationship, Drug
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Flow Cytometry
- G2 Phase Cell Cycle Checkpoints -- drug effects
- Human Umbilical Vein Endothelial Cells -- drug effects
- Humans
- MAP Kinase Kinase Kinases -- metabolism
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Models, Molecular
- Molecular Structure
- Neovascularization, Physiologic -- drug effects
- Phosphatidylinositol 3-Kinase -- metabolism
- Phosphorylation
- Poly(ADP-ribose) Polymerases -- metabolism
- Protein Kinase Inhibitors -- chemistry
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-met -- antagonists & inhibitors
- Rats
- Rats, Sprague-Dawley
- Signal Transduction -- drug effects
- Stomach Neoplasms -- blood supply
- Time Factors
- Tissue Culture Techniques
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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