KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer.

Hong, Sang-Won

KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer. [electronic resource] - Cancer letters May 2013 - 74-82 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1872-7980

10.1016/j.canlet.2013.01.015 doi


Aminopyridines--chemistry
Angiogenesis Inhibitors--chemistry
Animals
Antigens, CD34--metabolism
Apoptosis--drug effects
Benzoxazoles--chemistry
Caspase 3--metabolism
Cell Line, Tumor
Cell Proliferation--drug effects
DNA Fragmentation
Dose-Response Relationship, Drug
Extracellular Signal-Regulated MAP Kinases--metabolism
Flow Cytometry
G2 Phase Cell Cycle Checkpoints--drug effects
Human Umbilical Vein Endothelial Cells--drug effects
Humans
MAP Kinase Kinase Kinases--metabolism
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Models, Molecular
Molecular Structure
Neovascularization, Physiologic--drug effects
Phosphatidylinositol 3-Kinase--metabolism
Phosphorylation
Poly(ADP-ribose) Polymerases--metabolism
Protein Kinase Inhibitors--chemistry
Proto-Oncogene Proteins c-akt--metabolism
Proto-Oncogene Proteins c-met--antagonists & inhibitors
Rats
Rats, Sprague-Dawley
Signal Transduction--drug effects
Stomach Neoplasms--blood supply
Time Factors
Tissue Culture Techniques
Tumor Burden--drug effects
Xenograft Model Antitumor Assays