P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse. [electronic resource]
Producer: 20130516Description: 2274-84 p. digitalISSN:- 1528-0020
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Cell Line, Tumor
- Class I Phosphatidylinositol 3-Kinases
- DNA Mutational Analysis
- Drug Resistance, Neoplasm -- genetics
- Gene Expression Regulation, Enzymologic -- physiology
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Lymphoma, Mantle-Cell -- drug therapy
- Phosphatidylinositol 3-Kinases -- genetics
- Phosphoinositide-3 Kinase Inhibitors
- Protein Kinase Inhibitors -- administration & dosage
- Purines -- administration & dosage
- Quinazolinones -- administration & dosage
- Recurrence
- Signal Transduction -- physiology
- Substrate Specificity
- Treatment Outcome
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Publication Type: Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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