P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse.

Iyengar, Sunil

P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse. [electronic resource] - Blood Mar 2013 - 2274-84 p. digital

Publication Type: Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1528-0020

10.1182/blood-2012-10-460832 doi


Antineoplastic Combined Chemotherapy Protocols--pharmacology
Cell Line, Tumor
Class I Phosphatidylinositol 3-Kinases
DNA Mutational Analysis
Drug Resistance, Neoplasm--genetics
Gene Expression Regulation, Enzymologic--physiology
Gene Expression Regulation, Neoplastic--drug effects
Humans
Lymphoma, Mantle-Cell--drug therapy
Phosphatidylinositol 3-Kinases--genetics
Phosphoinositide-3 Kinase Inhibitors
Protein Kinase Inhibitors--administration & dosage
Purines--administration & dosage
Quinazolinones--administration & dosage
Recurrence
Signal Transduction--physiology
Substrate Specificity
Treatment Outcome