HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation. [electronic resource]
Producer: 20130401Description: 289-99 p. digitalISSN:- 1938-3673
- Adenosine Triphosphate -- metabolism
- Animals
- Caspase 1 -- metabolism
- Cell Line
- Enzyme Activation -- drug effects
- Enzyme-Linked Immunosorbent Assay
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Immunoblotting
- Inflammasomes -- drug effects
- Interleukin-1beta -- biosynthesis
- Mice
- Monocytes -- drug effects
- Receptors, Purinergic P2X7 -- metabolism
- Signal Transduction -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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