HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation.

Liao, Yi-Hsiang

HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation. [electronic resource] - Journal of leukocyte biology Feb 2013 - 289-99 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1938-3673

10.1189/jlb.0812409 doi


Adenosine Triphosphate--metabolism
Animals
Caspase 1--metabolism
Cell Line
Enzyme Activation--drug effects
Enzyme-Linked Immunosorbent Assay
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Immunoblotting
Inflammasomes--drug effects
Interleukin-1beta--biosynthesis
Mice
Monocytes--drug effects
Receptors, Purinergic P2X7--metabolism
Signal Transduction--drug effects