Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation. [electronic resource]
Producer: 20130311Description: 175-82 p. digitalISSN:- 1873-5835
- Apoptosis -- drug effects
- Caspases -- metabolism
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Chromosomes, Human, Pair 21
- Chromosomes, Human, Pair 8
- Dasatinib
- Enzyme Activation -- drug effects
- Humans
- K562 Cells
- Leukemia, Myeloid, Acute -- genetics
- Mutation
- Phosphorylation -- drug effects
- Protein Isoforms
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-kit -- genetics
- Pyrimidines -- pharmacology
- Thiazoles -- pharmacology
- Translocation, Genetic
- src-Family Kinases -- antagonists & inhibitors
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Publication Type: Journal Article
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