Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation.

Mpakou, Vassiliki E

Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation. [electronic resource] - Leukemia research Feb 2013 - 175-82 p. digital

Publication Type: Journal Article

1873-5835

10.1016/j.leukres.2012.10.011 doi


Apoptosis--drug effects
Caspases--metabolism
Cell Line, Tumor
Cell Proliferation--drug effects
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 8
Dasatinib
Enzyme Activation--drug effects
Humans
K562 Cells
Leukemia, Myeloid, Acute--genetics
Mutation
Phosphorylation--drug effects
Protein Isoforms
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins c-akt--metabolism
Proto-Oncogene Proteins c-kit--genetics
Pyrimidines--pharmacology
Thiazoles--pharmacology
Translocation, Genetic
src-Family Kinases--antagonists & inhibitors