Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes. [electronic resource]
Producer: 20130712Description: 362-71 p. digitalISSN:- 1521-009X
- Area Under Curve
- Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors
- Biotransformation
- Carbamates -- blood
- Computer Simulation
- Cytochrome P-450 CYP2C8
- Cytochrome P-450 CYP3A -- metabolism
- Cytochrome P-450 CYP3A Inhibitors
- Drug Interactions
- Enzyme Inhibitors -- blood
- Gemfibrozil -- blood
- Glucuronides -- pharmacology
- Humans
- Hypoglycemic Agents -- blood
- Itraconazole -- blood
- Least-Squares Analysis
- Liver -- drug effects
- Liver-Specific Organic Anion Transporter 1
- Models, Biological
- Nonlinear Dynamics
- Organic Anion Transporters -- antagonists & inhibitors
- Piperidines -- blood
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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