Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes.

Kudo, Toshiyuki

Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Feb 2013 - 362-71 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1521-009X

10.1124/dmd.112.049460 doi


Area Under Curve
Aryl Hydrocarbon Hydroxylases--antagonists & inhibitors
Biotransformation
Carbamates--blood
Computer Simulation
Cytochrome P-450 CYP2C8
Cytochrome P-450 CYP3A--metabolism
Cytochrome P-450 CYP3A Inhibitors
Drug Interactions
Enzyme Inhibitors--blood
Gemfibrozil--blood
Glucuronides--pharmacology
Humans
Hypoglycemic Agents--blood
Itraconazole--blood
Least-Squares Analysis
Liver--drug effects
Liver-Specific Organic Anion Transporter 1
Models, Biological
Nonlinear Dynamics
Organic Anion Transporters--antagonists & inhibitors
Piperidines--blood