Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice. [electronic resource]
Producer: 20130102Description: 325-37 p. digitalISSN:- 1097-4199
- Analysis of Variance
- Animals
- Behavior, Animal -- physiology
- Biophysics
- Dendritic Spines -- classification
- Disease Models, Animal
- Electric Stimulation
- Excitatory Postsynaptic Potentials -- drug effects
- Exploratory Behavior -- physiology
- Extracellular Signal-Regulated MAP Kinases -- genetics
- Female
- Fragile X Mental Retardation Protein -- genetics
- Fragile X Syndrome -- genetics
- Gene Expression Regulation -- genetics
- Hippocampus -- pathology
- In Vitro Techniques
- Interpersonal Relations
- Long-Term Synaptic Depression -- drug effects
- Male
- Maze Learning -- physiology
- Membrane Potentials -- drug effects
- Methoxyhydroxyphenylglycol -- analogs & derivatives
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Motor Activity -- genetics
- Mutation -- genetics
- Neurons -- classification
- Patch-Clamp Techniques
- Phenotype
- Phosphorylation -- genetics
- Recognition, Psychology -- physiology
- Ribosomal Protein S6 Kinases, 70-kDa -- deficiency
- Rotarod Performance Test
- Synapses -- drug effects
- TOR Serine-Threonine Kinases -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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