Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice.

Bhattacharya, Aditi

Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice. [electronic resource] - Neuron Oct 2012 - 325-37 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

1097-4199

10.1016/j.neuron.2012.07.022 doi


Analysis of Variance
Animals
Behavior, Animal--physiology
Biophysics
Dendritic Spines--classification
Disease Models, Animal
Electric Stimulation
Excitatory Postsynaptic Potentials--drug effects
Exploratory Behavior--physiology
Extracellular Signal-Regulated MAP Kinases--genetics
Female
Fragile X Mental Retardation Protein--genetics
Fragile X Syndrome--genetics
Gene Expression Regulation--genetics
Hippocampus--pathology
In Vitro Techniques
Interpersonal Relations
Long-Term Synaptic Depression--drug effects
Male
Maze Learning--physiology
Membrane Potentials--drug effects
Methoxyhydroxyphenylglycol--analogs & derivatives
Mice
Mice, Inbred C57BL
Mice, Transgenic
Motor Activity--genetics
Mutation--genetics
Neurons--classification
Patch-Clamp Techniques
Phenotype
Phosphorylation--genetics
Recognition, Psychology--physiology
Ribosomal Protein S6 Kinases, 70-kDa--deficiency
Rotarod Performance Test
Synapses--drug effects
TOR Serine-Threonine Kinases--genetics