Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex. [electronic resource]
Producer: 20130625Description: 231-43 p. digitalISSN:- 1432-0533
- Adult
- Aged
- Aged, 80 and over
- Blotting, Western
- Cell Count
- Cerebral Cortex -- pathology
- Down-Regulation
- Female
- Genetic Vectors
- Gyrus Cinguli -- pathology
- Heat-Shock Proteins -- biosynthesis
- Humans
- Immunohistochemistry
- Lentivirus -- genetics
- Male
- Middle Aged
- Mitochondria -- pathology
- Multiple Sclerosis -- genetics
- Neurons -- pathology
- Oxidation-Reduction
- Oxidative Phosphorylation
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Pyramidal Cells -- pathology
- RNA, Small Interfering -- genetics
- Reactive Oxygen Species -- metabolism
- Real-Time Polymerase Chain Reaction
- Tissue Banks
- Transcription Factors -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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