Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex.

Witte, Maarten E

Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex. [electronic resource] - Acta neuropathologica Feb 2013 - 231-43 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1432-0533

10.1007/s00401-012-1052-y doi


Adult
Aged
Aged, 80 and over
Blotting, Western
Cell Count
Cerebral Cortex--pathology
Down-Regulation
Female
Genetic Vectors
Gyrus Cinguli--pathology
Heat-Shock Proteins--biosynthesis
Humans
Immunohistochemistry
Lentivirus--genetics
Male
Middle Aged
Mitochondria--pathology
Multiple Sclerosis--genetics
Neurons--pathology
Oxidation-Reduction
Oxidative Phosphorylation
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Pyramidal Cells--pathology
RNA, Small Interfering--genetics
Reactive Oxygen Species--metabolism
Real-Time Polymerase Chain Reaction
Tissue Banks
Transcription Factors--biosynthesis