Extinction of aversive memories associated with morphine withdrawal requires ERK-mediated epigenetic regulation of brain-derived neurotrophic factor transcription in the rat ventromedial prefrontal cortex. [electronic resource]
Producer: 20130117Description: 13763-75 p. digitalISSN:- 1529-2401
- Acetylation -- drug effects
- Animals
- Association Learning -- drug effects
- Avoidance Learning -- physiology
- Brain-Derived Neurotrophic Factor -- biosynthesis
- Butadienes -- pharmacology
- Chromatin Assembly and Disassembly -- drug effects
- Conditioning, Classical -- drug effects
- Cyclic AMP Response Element-Binding Protein -- physiology
- Epigenetic Repression -- drug effects
- Extinction, Psychological -- physiology
- Histone Deacetylase Inhibitors -- pharmacology
- Histones -- physiology
- MAP Kinase Signaling System -- drug effects
- Male
- Morphine -- toxicity
- Morphine Dependence -- physiopathology
- Nitriles -- pharmacology
- Prefrontal Cortex -- physiology
- Protein Kinase Inhibitors -- pharmacology
- Protein Processing, Post-Translational -- drug effects
- Rats
- Rats, Sprague-Dawley
- Receptor, trkB -- antagonists & inhibitors
- Receptors, N-Methyl-D-Aspartate -- physiology
- Reward
- Substance Withdrawal Syndrome -- physiopathology
- Transcription, Genetic
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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