Extinction of aversive memories associated with morphine withdrawal requires ERK-mediated epigenetic regulation of brain-derived neurotrophic factor transcription in the rat ventromedial prefrontal cortex.

Wang, Wei-Sheng

Extinction of aversive memories associated with morphine withdrawal requires ERK-mediated epigenetic regulation of brain-derived neurotrophic factor transcription in the rat ventromedial prefrontal cortex. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Oct 2012 - 13763-75 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1529-2401

10.1523/JNEUROSCI.1991-12.2012 doi


Acetylation--drug effects
Animals
Association Learning--drug effects
Avoidance Learning--physiology
Brain-Derived Neurotrophic Factor--biosynthesis
Butadienes--pharmacology
Chromatin Assembly and Disassembly--drug effects
Conditioning, Classical--drug effects
Cyclic AMP Response Element-Binding Protein--physiology
Epigenetic Repression--drug effects
Extinction, Psychological--physiology
Histone Deacetylase Inhibitors--pharmacology
Histones--physiology
MAP Kinase Signaling System--drug effects
Male
Morphine--toxicity
Morphine Dependence--physiopathology
Nitriles--pharmacology
Prefrontal Cortex--physiology
Protein Kinase Inhibitors--pharmacology
Protein Processing, Post-Translational--drug effects
Rats
Rats, Sprague-Dawley
Receptor, trkB--antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate--physiology
Reward
Substance Withdrawal Syndrome--physiopathology
Transcription, Genetic