Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis. (Record no. 22152932)

MARC details
000 -LEADER
fixed length control field 02342 a2200697 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250516113800.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 201302s 0 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1520-4804
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1021/jm300931y
Source of number or code doi
040 ## - CATALOGING SOURCE
Original cataloging agency NLM
Language of cataloging eng
Transcribing agency NLM
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Gerritz, Samuel W
264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Date of production, publication, distribution, manufacture, or copyright notice 20130226
245 00 - TITLE STATEMENT
Title Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.
Medium [electronic resource]
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Journal of medicinal chemistry
Date of publication, distribution, etc. Nov 2012
300 ## - PHYSICAL DESCRIPTION
Extent 9208-23 p.
Other physical details digital
500 ## - GENERAL NOTE
General note Publication Type: Journal Article
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Amyloid Precursor Protein Secretases
General subdivision antagonists & inhibitors
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Amyloid beta-Peptides
General subdivision metabolism
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Amyloid beta-Protein Precursor
General subdivision genetics
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Animals
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aspartic Acid Endopeptidases
General subdivision antagonists & inhibitors
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Brain
General subdivision metabolism
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cell Line
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Crystallography, X-Ray
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Guanidines
General subdivision chemical synthesis
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Isoxazoles
General subdivision chemical synthesis
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Models, Molecular
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Molecular Structure
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Mutation
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Peptide Fragments
General subdivision metabolism
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Protein Binding
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Radioligand Assay
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Rats
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Small Molecule Libraries
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Solid-Phase Synthesis Techniques
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Solutions
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Structure-Activity Relationship
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Zhai, Weixu
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Shi, Shuhao
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Zhu, Shirong
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Toyn, Jeremy H
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Meredith, Jere E
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Iben, Lawrence G
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Burton, Catherine R
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Albright, Charles F
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Good, Andrew C
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Tebben, Andrew J
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Muckelbauer, Jodi K
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Camac, Daniel M
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Metzler, William
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Cook, Lynda S
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Padmanabha, Ramesh
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Lentz, Kimberley A
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Sofia, Michael J
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Poss, Michael A
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Macor, John E
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Thompson, Lorin A
773 0# - HOST ITEM ENTRY
Title Journal of medicinal chemistry
Related parts vol. 55
-- no. 21
-- p. 9208-23
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://doi.org/10.1021/jm300931y">https://doi.org/10.1021/jm300931y</a>
Public note Available from publisher's website

No items available.