A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy. [electronic resource]
Producer: 20150624Description: R116 p. digitalISSN:- 1465-542X
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal, Humanized -- chemistry
- Antibody-Dependent Cell Cytotoxicity -- immunology
- Cell Line
- Disease Models, Animal
- Female
- Humans
- Matrix Metalloproteinases -- metabolism
- Mice
- Molecular Sequence Data
- Neoplasms -- drug therapy
- Protein Binding
- Proteolysis
- Receptor, ErbB-2 -- antagonists & inhibitors
- Receptors, IgG -- metabolism
- Trastuzumab
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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