A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy.

Fan, Xuejun

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy. [electronic resource] - Breast cancer research : BCR Aug 2012 - R116 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1465-542X

10.1186/bcr3240 doi


Amino Acid Sequence
Animals
Antibodies, Monoclonal, Humanized--chemistry
Antibody-Dependent Cell Cytotoxicity--immunology
Cell Line
Disease Models, Animal
Female
Humans
Matrix Metalloproteinases--metabolism
Mice
Molecular Sequence Data
Neoplasms--drug therapy
Protein Binding
Proteolysis
Receptor, ErbB-2--antagonists & inhibitors
Receptors, IgG--metabolism
Trastuzumab
Xenograft Model Antitumor Assays