A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation. [electronic resource]
Producer: 20130404Description: 310-9 p. digitalISSN:- 1029-2292
- Animals
- Betacellulin
- Breast Neoplasms -- drug therapy
- CHO Cells
- Cell Line
- Cricetinae
- ErbB Receptors -- genetics
- Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors
- Female
- HEK293 Cells
- Humans
- I-kappa B Proteins -- antagonists & inhibitors
- Immunoglobulin G -- genetics
- Intercellular Signaling Peptides and Proteins -- metabolism
- JNK Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- MCF-7 Cells
- Melanoma -- pathology
- Mice
- Neuregulin-1 -- antagonists & inhibitors
- Ovarian Neoplasms -- pathology
- Phosphorylation
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Receptor, ErbB-4
- Receptors, Fc -- genetics
- Recombinant Fusion Proteins -- genetics
- Signal Transduction
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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