A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation.

Koziolek, Eva J

A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation. [electronic resource] - Growth factors (Chur, Switzerland) Oct 2012 - 310-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1029-2292

10.3109/08977194.2012.709516 doi


Animals
Betacellulin
Breast Neoplasms--drug therapy
CHO Cells
Cell Line
Cricetinae
ErbB Receptors--genetics
Extracellular Signal-Regulated MAP Kinases--antagonists & inhibitors
Female
HEK293 Cells
Humans
I-kappa B Proteins--antagonists & inhibitors
Immunoglobulin G--genetics
Intercellular Signaling Peptides and Proteins--metabolism
JNK Mitogen-Activated Protein Kinases--antagonists & inhibitors
MCF-7 Cells
Melanoma--pathology
Mice
Neuregulin-1--antagonists & inhibitors
Ovarian Neoplasms--pathology
Phosphorylation
Proto-Oncogene Proteins c-akt--antagonists & inhibitors
Receptor, ErbB-4
Receptors, Fc--genetics
Recombinant Fusion Proteins--genetics
Signal Transduction
Xenograft Model Antitumor Assays