Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination. [electronic resource]
Producer: 20121221Description: 767-76 p. digitalISSN:- 1521-0111
- Antineoplastic Agents -- pharmacology
- Ataxia Telangiectasia Mutated Proteins
- Benzimidazoles -- pharmacology
- Cell Cycle Checkpoints
- Cell Cycle Proteins -- metabolism
- Cell Line, Tumor
- Cell Survival -- drug effects
- Checkpoint Kinase 1
- Checkpoint Kinase 2
- DNA Damage
- DNA Repair
- Drug Synergism
- Enzyme Activation
- Female
- Floxuridine -- pharmacology
- Homologous Recombination
- Humans
- Ovarian Neoplasms -- pathology
- PTEN Phosphohydrolase -- genetics
- Poly(ADP-ribose) Polymerase Inhibitors
- Protein Kinases -- metabolism
- Protein Serine-Threonine Kinases -- metabolism
- Signal Transduction
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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