Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination.

Huehls, Amelia M

Identification of DNA repair pathways that affect the survival of ovarian cancer cells treated with a poly(ADP-ribose) polymerase inhibitor in a novel drug combination. [electronic resource] - Molecular pharmacology Oct 2012 - 767-76 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1521-0111

10.1124/mol.112.080614 doi


Antineoplastic Agents--pharmacology
Ataxia Telangiectasia Mutated Proteins
Benzimidazoles--pharmacology
Cell Cycle Checkpoints
Cell Cycle Proteins--metabolism
Cell Line, Tumor
Cell Survival--drug effects
Checkpoint Kinase 1
Checkpoint Kinase 2
DNA Damage
DNA Repair
Drug Synergism
Enzyme Activation
Female
Floxuridine--pharmacology
Homologous Recombination
Humans
Ovarian Neoplasms--pathology
PTEN Phosphohydrolase--genetics
Poly(ADP-ribose) Polymerase Inhibitors
Protein Kinases--metabolism
Protein Serine-Threonine Kinases--metabolism
Signal Transduction