Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. [electronic resource]
Producer: 20130226Description: 676-88 p. digitalISSN:- 2211-1247
- Activating Transcription Factor 4 -- metabolism
- Animals
- Behavior, Animal -- drug effects
- Benzamides -- administration & dosage
- Brain -- drug effects
- Cognition -- drug effects
- Eukaryotic Initiation Factor-2 -- metabolism
- Exploratory Behavior -- drug effects
- Gene Deletion
- Grooming -- drug effects
- Humans
- Mice
- Mice, Knockout
- Motor Activity -- drug effects
- Organ Specificity -- drug effects
- Phosphorylation -- drug effects
- Piperidines -- administration & dosage
- Prefrontal Cortex -- drug effects
- Protein Biosynthesis -- drug effects
- Protein Serine-Threonine Kinases -- deficiency
- Receptors, N-Methyl-D-Aspartate -- metabolism
- Reflex, Startle -- drug effects
- Reversal Learning -- drug effects
- Rotarod Performance Test
- Schizophrenia -- enzymology
- eIF-2 Kinase -- deficiency
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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