Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.

Trinh, Mimi A

Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. [electronic resource] - Cell reports Jun 2012 - 676-88 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2211-1247

10.1016/j.celrep.2012.04.010 doi


Activating Transcription Factor 4--metabolism
Animals
Behavior, Animal--drug effects
Benzamides--administration & dosage
Brain--drug effects
Cognition--drug effects
Eukaryotic Initiation Factor-2--metabolism
Exploratory Behavior--drug effects
Gene Deletion
Grooming--drug effects
Humans
Mice
Mice, Knockout
Motor Activity--drug effects
Organ Specificity--drug effects
Phosphorylation--drug effects
Piperidines--administration & dosage
Prefrontal Cortex--drug effects
Protein Biosynthesis--drug effects
Protein Serine-Threonine Kinases--deficiency
Receptors, N-Methyl-D-Aspartate--metabolism
Reflex, Startle--drug effects
Reversal Learning--drug effects
Rotarod Performance Test
Schizophrenia--enzymology
eIF-2 Kinase--deficiency