Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo. [electronic resource]
Producer: 20121029Description: 2185-98 p. digitalISSN:- 1524-4636
- Amino Acid Sequence
- Animals
- Anti-Inflammatory Agents -- chemistry
- Blood Coagulation -- drug effects
- Calorimetry
- Cell Line, Tumor
- Chlorides
- Cloning, Molecular
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Factor Xa -- metabolism
- Factor Xa Inhibitors
- Female
- Ferric Compounds
- Fibrinolytic Agents -- chemistry
- HEK293 Cells
- Humans
- Inflammation -- blood
- Insect Proteins -- chemistry
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Molecular Weight
- Partial Thromboplastin Time
- Protein Binding
- Prothrombin Time
- Psychodidae -- chemistry
- Rats
- Receptor, PAR-2 -- antagonists & inhibitors
- Recombinant Proteins -- antagonists & inhibitors
- Salivary Glands -- chemistry
- Surface Plasmon Resonance
- Thromboplastin -- antagonists & inhibitors
- Thrombosis -- blood
- Time Factors
No physical items for this record
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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