Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo.

Collin, Nicolas

Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly Lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo. [electronic resource] - Arteriosclerosis, thrombosis, and vascular biology Sep 2012 - 2185-98 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

1524-4636

10.1161/ATVBAHA.112.253906 doi


Amino Acid Sequence
Animals
Anti-Inflammatory Agents--chemistry
Blood Coagulation--drug effects
Calorimetry
Cell Line, Tumor
Chlorides
Cloning, Molecular
Disease Models, Animal
Dose-Response Relationship, Drug
Factor Xa--metabolism
Factor Xa Inhibitors
Female
Ferric Compounds
Fibrinolytic Agents--chemistry
HEK293 Cells
Humans
Inflammation--blood
Insect Proteins--chemistry
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Molecular Weight
Partial Thromboplastin Time
Protein Binding
Prothrombin Time
Psychodidae--chemistry
Rats
Receptor, PAR-2--antagonists & inhibitors
Recombinant Proteins--antagonists & inhibitors
Salivary Glands--chemistry
Surface Plasmon Resonance
Thromboplastin--antagonists & inhibitors
Thrombosis--blood
Time Factors