RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells. [electronic resource]
Producer: 20130123Description: 1119-27 p. digitalISSN:- 1791-2423
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Breast Neoplasms -- drug therapy
- Caspase 3 -- biosynthesis
- Cell Line, Tumor
- Cell Movement -- drug effects
- Curcumin -- analogs & derivatives
- Diarylheptanoids
- Down-Regulation
- Female
- G2 Phase Cell Cycle Checkpoints -- drug effects
- Human Umbilical Vein Endothelial Cells -- drug effects
- Humans
- JNK Mitogen-Activated Protein Kinases -- biosynthesis
- Mice
- Phosphorylation
- Proliferating Cell Nuclear Antigen -- biosynthesis
- Proto-Oncogene Proteins c-akt -- genetics
- Receptor, ErbB-2 -- metabolism
- Receptors, Estrogen -- metabolism
- Signal Transduction -- drug effects
- p38 Mitogen-Activated Protein Kinases -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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