RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells.

Yadav, Babasaheb

RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells. [electronic resource] - International journal of oncology Sep 2012 - 1119-27 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1791-2423

10.3892/ijo.2012.1521 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Breast Neoplasms--drug therapy
Caspase 3--biosynthesis
Cell Line, Tumor
Cell Movement--drug effects
Curcumin--analogs & derivatives
Diarylheptanoids
Down-Regulation
Female
G2 Phase Cell Cycle Checkpoints--drug effects
Human Umbilical Vein Endothelial Cells--drug effects
Humans
JNK Mitogen-Activated Protein Kinases--biosynthesis
Mice
Phosphorylation
Proliferating Cell Nuclear Antigen--biosynthesis
Proto-Oncogene Proteins c-akt--genetics
Receptor, ErbB-2--metabolism
Receptors, Estrogen--metabolism
Signal Transduction--drug effects
p38 Mitogen-Activated Protein Kinases--biosynthesis