Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human. [electronic resource]
Producer: 20130117Description: 1785-96 p. digitalISSN:- 1521-009X
- ATP Binding Cassette Transporter, Subfamily B -- deficiency
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters -- deficiency
- Administration, Oral
- Animals
- Antineoplastic Agents -- administration & dosage
- Area Under Curve
- Biological Availability
- Biotransformation
- Brain -- metabolism
- Breast Neoplasms -- drug therapy
- Bridged Bicyclo Compounds, Heterocyclic -- administration & dosage
- Cell Membrane Permeability
- Dogs
- Drug Dosage Calculations
- Female
- Half-Life
- Hepatocytes -- metabolism
- Humans
- Injections, Intravenous
- Intestinal Absorption
- Liver -- metabolism
- MCF-7 Cells
- Macaca fascicularis
- Madin Darby Canine Kidney Cells
- Male
- Metabolic Clearance Rate
- Mice
- Mice, Knockout
- Models, Biological
- Phosphatidylinositol 3-Kinase -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Protein Binding
- Protein Kinase Inhibitors -- administration & dosage
- Pyrimidines -- administration & dosage
- Rats
- Rats, Sprague-Dawley
- Receptor, ErbB-2 -- genetics
- Species Specificity
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Tissue Distribution
- Transfection
- Xenograft Model Antitumor Assays
- ATP-Binding Cassette Sub-Family B Member 4
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Publication Type: Journal Article
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