Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human.
Salphati, Laurent
Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Sep 2012 - 1785-96 p. digital
Publication Type: Journal Article
1521-009X
10.1124/dmd.112.046052 doi
ATP Binding Cassette Transporter, Subfamily B--deficiency
ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP-Binding Cassette Transporters--deficiency
Administration, Oral
Animals
Antineoplastic Agents--administration & dosage
Area Under Curve
Biological Availability
Biotransformation
Brain--metabolism
Breast Neoplasms--drug therapy
Bridged Bicyclo Compounds, Heterocyclic--administration & dosage
Cell Membrane Permeability
Dogs
Drug Dosage Calculations
Female
Half-Life
Hepatocytes--metabolism
Humans
Injections, Intravenous
Intestinal Absorption
Liver--metabolism
MCF-7 Cells
Macaca fascicularis
Madin Darby Canine Kidney Cells
Male
Metabolic Clearance Rate
Mice
Mice, Knockout
Models, Biological
Phosphatidylinositol 3-Kinase--metabolism
Phosphoinositide-3 Kinase Inhibitors
Protein Binding
Protein Kinase Inhibitors--administration & dosage
Pyrimidines--administration & dosage
Rats
Rats, Sprague-Dawley
Receptor, ErbB-2--genetics
Species Specificity
TOR Serine-Threonine Kinases--antagonists & inhibitors
Tissue Distribution
Transfection
Xenograft Model Antitumor Assays
ATP-Binding Cassette Sub-Family B Member 4
Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Sep 2012 - 1785-96 p. digital
Publication Type: Journal Article
1521-009X
10.1124/dmd.112.046052 doi
ATP Binding Cassette Transporter, Subfamily B--deficiency
ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP-Binding Cassette Transporters--deficiency
Administration, Oral
Animals
Antineoplastic Agents--administration & dosage
Area Under Curve
Biological Availability
Biotransformation
Brain--metabolism
Breast Neoplasms--drug therapy
Bridged Bicyclo Compounds, Heterocyclic--administration & dosage
Cell Membrane Permeability
Dogs
Drug Dosage Calculations
Female
Half-Life
Hepatocytes--metabolism
Humans
Injections, Intravenous
Intestinal Absorption
Liver--metabolism
MCF-7 Cells
Macaca fascicularis
Madin Darby Canine Kidney Cells
Male
Metabolic Clearance Rate
Mice
Mice, Knockout
Models, Biological
Phosphatidylinositol 3-Kinase--metabolism
Phosphoinositide-3 Kinase Inhibitors
Protein Binding
Protein Kinase Inhibitors--administration & dosage
Pyrimidines--administration & dosage
Rats
Rats, Sprague-Dawley
Receptor, ErbB-2--genetics
Species Specificity
TOR Serine-Threonine Kinases--antagonists & inhibitors
Tissue Distribution
Transfection
Xenograft Model Antitumor Assays
ATP-Binding Cassette Sub-Family B Member 4