AML1-ETO targets and suppresses cathepsin G, a serine protease, which is able to degrade AML1-ETO in t(8;21) acute myeloid leukemia. [electronic resource]
Producer: 20130619Description: 1978-87 p. digitalISSN:- 1476-5594
- Apoptosis
- Cathepsin G -- genetics
- Cell Differentiation -- genetics
- Cell Line, Tumor
- Core Binding Factor Alpha 2 Subunit -- genetics
- DNA-Binding Proteins -- metabolism
- Down-Regulation
- Gene Expression Regulation, Leukemic
- HEK293 Cells
- HL-60 Cells
- HeLa Cells
- Hematopoiesis -- genetics
- Humans
- Immunologic Surveillance
- Leukemia, Myeloid, Acute -- genetics
- MDS1 and EVI1 Complex Locus Protein
- Oncogene Proteins, Fusion -- genetics
- Promoter Regions, Genetic
- Proto-Oncogenes
- RUNX1 Translocation Partner 1 Protein
- Transcription Factors -- metabolism
- Tumor Escape -- immunology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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