AML1-ETO targets and suppresses cathepsin G, a serine protease, which is able to degrade AML1-ETO in t(8;21) acute myeloid leukemia.
Jin, W
AML1-ETO targets and suppresses cathepsin G, a serine protease, which is able to degrade AML1-ETO in t(8;21) acute myeloid leukemia. [electronic resource] - Oncogene Apr 2013 - 1978-87 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5594
10.1038/onc.2012.204 doi
Apoptosis
Cathepsin G--genetics
Cell Differentiation--genetics
Cell Line, Tumor
Core Binding Factor Alpha 2 Subunit--genetics
DNA-Binding Proteins--metabolism
Down-Regulation
Gene Expression Regulation, Leukemic
HEK293 Cells
HL-60 Cells
HeLa Cells
Hematopoiesis--genetics
Humans
Immunologic Surveillance
Leukemia, Myeloid, Acute--genetics
MDS1 and EVI1 Complex Locus Protein
Oncogene Proteins, Fusion--genetics
Promoter Regions, Genetic
Proto-Oncogenes
RUNX1 Translocation Partner 1 Protein
Transcription Factors--metabolism
Tumor Escape--immunology
AML1-ETO targets and suppresses cathepsin G, a serine protease, which is able to degrade AML1-ETO in t(8;21) acute myeloid leukemia. [electronic resource] - Oncogene Apr 2013 - 1978-87 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-5594
10.1038/onc.2012.204 doi
Apoptosis
Cathepsin G--genetics
Cell Differentiation--genetics
Cell Line, Tumor
Core Binding Factor Alpha 2 Subunit--genetics
DNA-Binding Proteins--metabolism
Down-Regulation
Gene Expression Regulation, Leukemic
HEK293 Cells
HL-60 Cells
HeLa Cells
Hematopoiesis--genetics
Humans
Immunologic Surveillance
Leukemia, Myeloid, Acute--genetics
MDS1 and EVI1 Complex Locus Protein
Oncogene Proteins, Fusion--genetics
Promoter Regions, Genetic
Proto-Oncogenes
RUNX1 Translocation Partner 1 Protein
Transcription Factors--metabolism
Tumor Escape--immunology