A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes. [electronic resource]
Producer: 19901011Description: 6738-42 p. digitalISSN:- 0027-8424
- Animals
- Base Sequence
- Cell Division
- Cell Line
- Codon -- genetics
- DNA-Binding Proteins -- genetics
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Peptide Mapping
- Phosphatidylinositol 3-Kinases
- Phosphopeptides -- isolation & purification
- Phosphorylation
- Phosphotransferases -- metabolism
- Protein-Tyrosine Kinases -- genetics
- Proto-Oncogene Proteins -- biosynthesis
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-jun
- Proto-Oncogenes
- Receptor, Macrophage Colony-Stimulating Factor
- Signal Transduction
- Transcription Factors -- genetics
- Tyrosine
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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