A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.

Roussel, M F

A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Sep 1990 - 6738-42 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0027-8424

10.1073/pnas.87.17.6738 doi


Animals
Base Sequence
Cell Division
Cell Line
Codon--genetics
DNA-Binding Proteins--genetics
Humans
Mice
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Peptide Mapping
Phosphatidylinositol 3-Kinases
Phosphopeptides--isolation & purification
Phosphorylation
Phosphotransferases--metabolism
Protein-Tyrosine Kinases--genetics
Proto-Oncogene Proteins--biosynthesis
Proto-Oncogene Proteins c-fos
Proto-Oncogene Proteins c-jun
Proto-Oncogenes
Receptor, Macrophage Colony-Stimulating Factor
Signal Transduction
Transcription Factors--genetics
Tyrosine