Axitinib targeted cancer stemlike cells to enhance efficacy of chemotherapeutic drugs via inhibiting the drug transport function of ABCG2. [electronic resource]
Producer: 20121119Description: 887-98 p. digitalISSN:- 1528-3658
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters -- antagonists & inhibitors
- Animals
- Antineoplastic Agents -- pharmacology
- Axitinib
- Biological Transport -- drug effects
- Cell Line, Tumor
- Drug Resistance, Neoplasm -- genetics
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Imidazoles -- pharmacology
- Indazoles -- pharmacology
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred NOD
- Mice, Nude
- Mice, SCID
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Neoplasm Proteins -- antagonists & inhibitors
- Neoplasms -- genetics
- Neoplastic Stem Cells -- drug effects
- Phosphorylation -- drug effects
- Proto-Oncogene Proteins c-akt -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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