Axitinib targeted cancer stemlike cells to enhance efficacy of chemotherapeutic drugs via inhibiting the drug transport function of ABCG2.

Wang, Fang

Axitinib targeted cancer stemlike cells to enhance efficacy of chemotherapeutic drugs via inhibiting the drug transport function of ABCG2. [electronic resource] - Molecular medicine (Cambridge, Mass.) Jul 2012 - 887-98 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1528-3658

10.2119/molmed.2011.00444 doi


ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP-Binding Cassette Transporters--antagonists & inhibitors
Animals
Antineoplastic Agents--pharmacology
Axitinib
Biological Transport--drug effects
Cell Line, Tumor
Drug Resistance, Neoplasm--genetics
Female
Gene Expression Regulation, Neoplastic--drug effects
Humans
Imidazoles--pharmacology
Indazoles--pharmacology
Male
Mice
Mice, Inbred BALB C
Mice, Inbred NOD
Mice, Nude
Mice, SCID
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3--metabolism
Neoplasm Proteins--antagonists & inhibitors
Neoplasms--genetics
Neoplastic Stem Cells--drug effects
Phosphorylation--drug effects
Proto-Oncogene Proteins c-akt--metabolism
Xenograft Model Antitumor Assays