Mallory-Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells. [electronic resource]
Producer: 20120725Description: 318-26 p. digitalISSN:- 1096-0945
- Animals
- Blotting, Western
- Carcinoma, Hepatocellular -- genetics
- Cell Cycle Checkpoints
- Cell Nucleus -- drug effects
- Cyclin D1 -- metabolism
- Cyclin-Dependent Kinase Inhibitor p27 -- metabolism
- DNA Methylation
- DNA-Binding Proteins -- genetics
- Enhancer of Zeste Homolog 2 Protein
- Hepatitis, Alcoholic -- genetics
- Hepatocytes -- drug effects
- Histones -- metabolism
- Humans
- Immunohistochemistry
- Liver -- drug effects
- Liver Neoplasms -- genetics
- Lysine -- metabolism
- Mallory Bodies -- drug effects
- Methylation
- Mice
- Microscopy, Electron
- Polycomb Repressive Complex 2
- Proliferating Cell Nuclear Antigen -- metabolism
- Pyridines -- toxicity
- Reverse Transcriptase Polymerase Chain Reaction
- S-Adenosylmethionine -- pharmacology
- Transcription Factors -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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