Mallory-Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells.

French, B A

Mallory-Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells. [electronic resource] - Experimental and molecular pathology Jun 2012 - 318-26 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1096-0945

10.1016/j.yexmp.2012.02.003 doi


Animals
Blotting, Western
Carcinoma, Hepatocellular--genetics
Cell Cycle Checkpoints
Cell Nucleus--drug effects
Cyclin D1--metabolism
Cyclin-Dependent Kinase Inhibitor p27--metabolism
DNA Methylation
DNA-Binding Proteins--genetics
Enhancer of Zeste Homolog 2 Protein
Hepatitis, Alcoholic--genetics
Hepatocytes--drug effects
Histones--metabolism
Humans
Immunohistochemistry
Liver--drug effects
Liver Neoplasms--genetics
Lysine--metabolism
Mallory Bodies--drug effects
Methylation
Mice
Microscopy, Electron
Polycomb Repressive Complex 2
Proliferating Cell Nuclear Antigen--metabolism
Pyridines--toxicity
Reverse Transcriptase Polymerase Chain Reaction
S-Adenosylmethionine--pharmacology
Transcription Factors--genetics